Too many ends: aberrant transposition

Too many ends: aberrant transposition.

A recent study by Zhang and colleagues published in the March 15, 2009, issue of Genes & Development (pp. 755-765) demonstrates that maize Ac/Ds transposons mediate translocations and other rearrangements through aberrant execution of the normal transposition process. Ac transposase uses one end from each of two neighboring elements in these events, which may happen more commonly than previousl...

How many "me-too" drugs is too many?

ON AUGUST 3, 2009, THE US FOOD AND DRUG ADministration (FDA) approved pitavastatin (Livalo), making it the eighth statin approved for use in the United States and seventh currently available for sale. This approval comes almost a quarter century after that for the first member of the class, lovastatin, 8 years after generic lovastatin was approved and 4 years after 2 additional statins, pravast...

Therapeutic cytapheresis: too many platelets, too many white blood cells.

Myeloproliferative disorders may present with thrombocytosis and/or leukocytosis with symptoms ranging from minor to life-threatening. Therapeutic cytapheresis (TC), the removal of excess and/or abnormal cells such as platelets and white blood cells, can be used to rapidly reduce cells in the symptomatic patient. The patient's clinical status determines the need for TC as symptoms may not corre...

Too few physicians, or too many?

Rate Changes – Too many or too few ?